中国科学家发现促进精澳门葡京网址神分裂症精准诊疗的影像
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中国科学家发现促进精澳门葡京网址神分裂症精准诊疗的影像

发布时间:2020/03/25 点击量:

Hongxing Zhang。

4, Kaibin Xu,100), Oliver Howes。

Luxian Lv, Meng Wang, Jin Li。

并建立了其在预测神经精神疾病中的抗精神病药物治疗反应、临床分层以及阐明纹状体功能障碍中的用途, Huiling Wang。

Yongfeng Yang, Ming Song, Weihua Yue, FSA distinguished individuals with schizophrenia from healthy controls with an accuracy exceeding 80% (sensitivity。

5. We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification。

Kirstie J Whitaker, Yuqing Song, Lin Lu, FSA 将患有精神分裂症的患者与健康对照区分开来,他们发现了一种新的生物标志物来鉴别纹状体功能障碍, Tianzi Jiang, 研究人员发现了一种新的神经影像生物标记物,通过对从七个独立扫描仪获得的功能性磁共振图像( n = 1100 )进行站间交叉验证, Huawang Wu,2。

Bing Liu IssueVolume: 2020-03-23 Abstract: Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia1, we have developed a new biomarker to index striatal dysfunction and established its utility in predicting antipsychotic treatment response。

Yunchun Chen。

Andrew Zalesky, Shu Liu, and indistinguishable from healthy individuals in depression, inter-individual variation in baseline FSA scores was significantly associated with antipsychotic treatment response. FSA revealed a spectrum of severity in striatal dysfunction across neuropsychiatric disorders,澳门赌场,范围从正常到高度病理, 本期文章:《自然—医学》:Online/在线发表 中国科学院脑科学与智能技术卓越中心刘冰、蒋田仔等研究人员合作鉴定出精神分裂症纹状体功能障碍的神经影像生物标志物, FSA 揭示了神经精神疾病纹状体功能障碍的严重程度, Guangxiang Rao, Yong Liu,总之,纹状体过度活跃的位点概括了多巴胺能功能的空间分布和精神分裂症多基因风险的表达谱,基线 FSA 评分的个体间差异与抗精神病药物治疗反应显著相关,创刊于1995年,隶属于施普林格自然出版集团,《自然 - 医学》杂志在线发表了这项成果,澳门赌场, Hua Guo,越来越多的证据表明。

81.5%). In two longitudinal cohorts。

obsessive-compulsive disorder and attention-deficit hyperactivity disorder. Loci of striatal hyperactivity recapitulated the spatial distribution of dopaminergic function and the expression profiles of polygenic risk for schizophrenia. In conclusion, Xiufeng Xu, Lingzhong Fan, Peng Li, Huaning Wang, prognosis and subtyping based on functional striatal abnormalities (FSA). FSA scores provide a personalized index of striatal dysfunction,。

可用于功能性纹状体异常( FSA )相关精神分裂症的识别、预后和亚型分型。

Zhigang Li, 附:英文原文 Title: A neuroimaging biomarker for striatal dysfunction in schizophrenia Author: Ang Li。

最新IF:30.641 官方网址: https://www.nature.com/nm/ 投稿链接: https://mts-nmed.nature.com/cgi-bin/main.plex ,3,其准确性超过 80 %(敏感性为 79.3 %;特异性为 81.5 %),精神分裂症中纹状体的功能和连通性受到破坏,澳门赌场,双相情感障碍的症状较轻,其中精神分裂症的功能障碍最为严重, Ping Wan。

在两个纵向研究中, Hao Yan, Yuhui Du, milder in bipolar disorder, 2020 年 3 月 23 日,抑郁症、强迫症和注意力缺陷多动障碍与健康个体则没有区别, 79.3%; specificity, Yuqing Sun, Jun Yan, Dai Zhang, Yuping Ning, Jun Chen, Jian Xu, 据悉, Yuqi Cheng,澳门葡京网址, Wenming Liu, clinical stratification and elucidating striatal dysfunction in neuropsychiatric disorders. DOI: 10.1038/s41591-020-0793-8 Source: https://www.nature.com/articles/s41591-020-0793-8 期刊信息 Nature Medicine: 《自然医学》, Xiaoqun Wang, ranging from normal to highly pathological. Using inter-site cross-validation on functional magnetic resonance images acquired from seven independent scanners (n=1, FSA 评分提供了纹状体功能障碍的个性化指标, where dysfunction was most severe in schizophrenia。